Biomimetic 3D Printing of Hierarchical and Interconnected Porous Hydroxyapatite Structures with High Mechanical Strength for Bone Cell Culture

Interconnected porous hydroxyapatite ceramics for bone tissue engineering.

Several porous calcium hydroxyapatite (HA) ceramics have been used clinically as bone substitutes, but most of them possessed few interpore connections, resulting in pathological fracture probably due to poor bone formation within the substitute. We recently developed a fully interconnected porous HA ceramic (IP-CHA) by adopting the 'foam-gel' technique. The IP-CHA had a three-dimensional struc...

Assessment of bone ingrowth potential of biomimetic hydroxyapatite and brushite coated porous E-beam structures

The bone ingrowth potential of biomimetic hydroxyapatite and brushite coatings applied on porous E-beam structure was examined in goats and compared to a similar uncoated porous structure and a conventional titanium plasma spray coating. Specimens were implanted in the iliac crest of goats for a period of 3 (4 goats) or 15 weeks (8 goats). Mechanical implant fixation generated by bone ingrowth ...

Multiscale Modelling and Mechanical Characterization of Porous Hierarchical Hydroxyapatite

Group G 2 So far, bone surgeons have implemented three techniques for bone repair: autografting (healthy bone tissue taken from the patient’s own body), allografting (healthy bone tissue taken from a donor) and synthetic bone graft substitutes (artificial biomaterial similar to bone). Autografting is considered as the ‘gold’ standard. However the volume of bone that can be safely harvested is l...

Multi-scale Modelling and Mechanical Characterization of Porous Hierarchical Hydroxyapatite

Hydroxyapatite scaffolds for bone tissue engineering made by 3D printing.

Nowadays, there is a significant need for synthetic bone replacement materials used in bone tissue engineering (BTE). Rapid prototyping and especially 3D printing is a suitable technique to create custom implants based on medical data sets. 3D printing allows to fabricate scaffolds based on Hydroxyapatite with complex internal structures and high resolution. To determine the in vitro behaviour ...